文献类型：期刊文献

英文题名：Iron- or Copper-Catalyzed Trifluoromethylation of Acrylamide-Tethered Alkylidenecyclopropanes: Facile Synthesis of CF3-Containing Polycyclic Benzazepine Derivatives

作者：Yu, Liu-Zhu[1,2];Xu, Qin[1,2];Tang, Xiang-Yiang[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2016

卷号：6

期号：2

起止页码：526

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20160701917366);WOS:【SCI-EXPANDED(收录号:WOS:000369774900003)】；

基金：We are grateful for financial support from the National Basic Research Program of China ((973)-2015CB856603) and the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, and 21572052).

语种：英文

外文关键词：iron or copper catalysis; alkylidenecyclopropanes; tetracyclic benzazepine derivatives; radical addition; activated alkenes; ring opening

摘要：A novel iron- or copper-catalyzed trifluoromethylation of acrylamide-tethered alkylidenecyclopropanes with Togni reagent II to construct CF3-containing tetracyclic benzazepine derivatives under mild and convenient conditions has been disclosed. The chemoselective addition of in situ generated trifluoromethyl radical onto the activated alkenes triggers the reaction followed by a ring-opening process of alkylidenecyclopropanes, leading to the formation of two types of CF3-containing tetracyclic benzazepine derivatives in moderate to good yields, respectively, with excellent functional group tolerance.