文献类型：期刊文献

英文题名：Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery

作者：Xiang, Hui-Jing[1];Guo, Min[1];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2017

卷号：2017

期号：12

起止页码：1586

外文期刊名：EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

收录：;EI(收录号：20231713978982);WOS:【SCI-EXPANDED(收录号:WOS:000397853700007)】；

基金：We acknowledge financial support from the National Nature Science Foundation of China (nos. 21271072, 21571062), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Shanghai Pujiang Program (no. 13J1401900). We express our gratitude to our graduate students and collaborators whose names appear in the literature and the work described here.

语种：英文

外文关键词：Nitrogen oxides; Nitric oxide; Drug delivery; Nitric oxide donors; Transition metals; Ruthenium nitrosyls; Photolysis; Nanoplatforms

摘要：Nitric oxide (NO) is an endogenously produced biological signaling compound, involved not only in various physiological processes but also in cancer biology. The potential therapeutic applications of NO in regulation of vascular tone, anticancer, antibacterial, anti-inflammatory, and wound healing processes has resulted in an explosion of research interest in NO donor compounds and in related materials capable of delivering NO to desired sites. Transition-metal nitrosyls such as those of ruthenium (Ru-NOs) are photolabile NO donors from which NO release can be manipulated on demand by application of light. This enables control of spatiotemporal delivery and of optimal NO dosage at a desired site and time. In this microreview we highlight advances of the past few years in rational ligand design, the sensitization of metal nitrosyls (especially Ru-NOs) by use of light from ultraviolet (UV) to near-infrared (NIR) wavelengths for efficient NO release, and integration of metal nitrosyls with various nanoplatforms for photocontrolled targeted NO delivery.