文献类型：期刊文献

中文题名：Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

英文题名：Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

作者：Xiulei Chen[1];Haowu Jia[1];Zhong Li[1,2];Xiaoyong Xu[1,2]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;[2]Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

年份：2019

卷号：30

期号：6

起止页码：1207

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：financial supported by the National Natural Science Foundation of China(No. 21672061);National Key Research Program of China(Nos.2017YFD0200505 and 2018YFD0200105);the Fundamental Research Funds for the Central Universities(No. 222201718004)

语种：英文

中文关键词：1;2;3-Benzotriazin-4-one;Heterocycle;M.;incognita;Nematicidal;activity;Fragment

外文关键词：1,2,3-Benzotriazin-4-one;Heterocycle;M.incognita;Nematicidal activity;Fragment

摘要：To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification.
To explore new skeleton with nematicidal activity,a series of novel 1,2.3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton.Their inhibitory activities in vivo were evaluated against Meloidogyne incognita.The newly prepared compounds A6,A8,A21,A28 and A38 exhibited more than50% inhibition at the concentration of 20 mg/L.Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L.The nematicidal activities varied significantly depending on the types and positions of the substituents,which provided guidance for further structure modification.