文献类型：期刊文献

中文题名：Palladium-Catalyzed[4+4]Cycloaddition of Homo-TMM All-Carbon 1,4-Dipole Precursors for Construction of Benzofuro[3,2-b]azocines and Furo[3,2-b]azocines

作者：Ying Chen[1];Meng Zang[1];Weije Wang[1];Yang-zi Liu[2];Xiaoyan Luo[1];Wei-Ping Deng[1,2]

机构：[1]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,College of Chemistry and Materials Science,ZhejiangNormal University,Jinhua,Zhejiang 321004,China

年份：2023

卷号：41

期号：21

起止页码：2825

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：We are grateful for financial support from National Key Research and Development Program of China(2021YFA0804900);the NSFC(22171082,21971062);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2022R01007);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism.

语种：英文

中文关键词：Pd-catalyzed;[4+4]cycloaddition;Homo-TMM 1,4-dipoles;Methodology and reactions;Medium-ring compounds Regioselectivity

摘要：We developed a novel Pd-catalyzed[4+4]cycloaddition of(benzo)furan-derived azadienes with homo-TMM all-carbon 1,4-dipoles in situ generated fromα-allyl malonate derivatives,affording an array of benzofuro[3,2-b]azocines and furo[3,2-b]azocines with good to excellent yields(up to 96%)and exclusive regioselectivities.This methodology featured mild reaction conditions and good functional group tolerance.The synthetic utility was demonstrated by a gram-scale reaction.Furthermore,the catalytic asymmetric[4+4]cycloaddition version has also been explored.