文献类型：期刊文献

英文题名：An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction

作者：Lei, Min[1];Ma, Lei[1];Hu, Lihong[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2010

卷号：141

期号：9

起止页码：1005

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：;EI(收录号：20242616551633);WOS:【SCI-EXPANDED(收录号:WOS:000281106200011)，CCR-EXPANDED(收录号:WOS:000281106200011)】；

基金：This work was supported by the Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program'' (grants 2009ZX09301-001, 2009ZX09102), the Chinese National High-Tech R&D Program (grants 2007AA02Z147), the National Natural Science Foundation of China (grants 90713046, 30772638, 30925040), and the CAS Foundation (grant KSCX2-YW-R-179).

语种：英文

外文关键词：Multicomponent reactions; Aldehyde; Organocatalyst; Green chemistry

摘要：A Biginelli-type three-component reaction involving cyclopentanone, aromatic aldehyde, and urea or thiourea for preparation of pyrimidinone derivatives under neat conditions is described. This condensation reaction can also take place smoothly in the presence of vitamin B(1) in EtOH at 80 A degrees C in good yield. The procedure is simple, high-yielding, time-saving, and environment friendly.