文献类型：期刊文献

英文题名：Efficient synthetic supramolecular channels and their light-deactivated ion transport in bilayer lipid membranes

作者：Bao, Chunyan[1];Ma, Meixin[1];Meng, Funa[1];Lin, Qiuning[1];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：39

期号：8

起止页码：6297

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000358512200056)】；

基金：This work was supported by NSFC (51273064, 21472044), Innovation Program of Shanghai Municipal Education Commission and Fundamental Research Funds for the Central University.

语种：英文

摘要：Inspired by the critical role of ion channel proteins in the regulation of cellular activities, here we developed a new type of synthetic ion channel by simple benzocrown ether-based derivatives M1 and M2, where M1 had a dodecyl tail and M2 had a diethylene glycol-conjugated dodecyl tail. Being amphiphilic in nature, the two small molecules were assumed to form crown ether channels through supramolecular interactions in bilayer lipid membranes (BLMs). The efficient ion transport was investigated by both a fluorescence-based vesicle assay and a planar bilayer conductance measurement, and M2 with diethylene glycol substitution exhibited more efficient activity comparable to amphotericin B. Moreover, the presence of a photosensitive o-nitrobenzyl group provided the light-regulation to deactivate ion transport by destroying the channel assembly of the molecules in BLMs, which provides new opportunities for developing intelligent light-regulated systems for biomedical applications based on synthetic small molecules.