文献类型：期刊文献

中文题名：层层组装构建蛋白质基多层结构及其生物医用研究进展

英文题名：Protein-based Multilayer Assembly:Fabrication and the Biomedical Application

作者：屈雪[1];吴刚[1];刘昌胜[1,2]

机构：[1]华东理工大学超细材料教育部重点实验室,上海200237;[2]华东理工大学生物反应器工程国家重点实验室,上海200237

年份：2014

期号：10

起止页码：13

中文期刊名：高分子通报

外文期刊名：Polymer Bulletin

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家自然科学基金(5110304);上海市教委科研创新重点项目(14ZZ060)

语种：中文

中文关键词：蛋白;层层自组装;生物医用功能

外文关键词：Protein;;Layer-by-Layer self assembly;;Biomedical application

摘要：对蛋白质基自组装多层结构的发展和生物医学应用进行了综述。详细介绍了蛋白质多层结构的组装原理、组装基元类型、不同物理结构如涂层、微胶囊和纳米管的制备技术。阐述了蛋白质多层结构在抗凝血、抗菌、生物活性涂层、药物控释和生物分离方面的应用。最后对蛋白质基组装体系的优势进行总结,对其进一步的发展方向作了展望。
This paper reviewed the development of protein-based multilayer assemblies.The assembling mechanisms,building blocks and physical morphologies such as coating,microcapsule and nanotubes of the protein assemblies were introduced in detail.Their biomedical applications such as antibacteriality,anticoagulation,bioactive coatings,controlled drug delivery and bioseparation were summarized as well.The advantages as well as the future developments of the protein multilayer assemblies were also addressed.