文献类型：期刊文献

英文题名：Probing disease-related proteins with fluorogenic composite materials

作者：He, Xiao-Peng[1,2];Zang, Yi[3];James, Tony D.[4];Li, Jia[3];Chen, Guo-Rong[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2015

卷号：44

期号：13

起止页码：4239

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356610100008)】；

基金：This research is supported by the 973 project (2013CB733700), the National Science Fund for Distinguished Young Scholars (81125023), the National Natural Science Foundation of China (21176076, 21202045), the Program of Shanghai Subject Chief Scientist (13XD1404300), the Key Project of Shanghai Science and Technology Commission (13NM1400900) and the Fundamental Research Funds for Central Universities. The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities.

语种：英文

摘要：Construction of composite materials based on the self-assembly of fluorescently labeled biomolecules with a variety of micro- or nano-quenching materials (by the Forster Resonance Energy Transfer mechanism) for the fluorogenic recognition of disease-related proteins has become a dynamic research topic in the field of fluorescence recognition. Here we summarize the recent progress on the composition of fluorescence dye-labeled biomolecules including sugars, peptides and nucleotides with organic (graphene and carbon nanotubes) and inorganic (gold nanoparticles) materials. Their application in the fluorescence detection of proteins and enzymes on both the molecular and cellular levels is discussed. Perspectives are proposed with respect to the future directions of employing these composite materials in the recognition of pathological proteins.