文献类型：期刊文献

英文题名：Facile Preparation of Core-Shell Magnetic Metal-Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides

作者：Xiong, Zhichao[1,2];Ji, Yongsheng[2,3];Fang, Chunli[2];Zhang, Quanqing[2];Zhang, Lingyi[1];Ye, Mingliang[2];Zhang, Weibing[1,2];Zou, Hanfa[2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Dept Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China;[3]Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450008, Peoples R China

年份：2014

卷号：20

期号：24

起止页码：7389

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20142417823950);WOS:【SCI-EXPANDED(收录号:WOS:000337617500026)】；

基金：Financial support is gratefully acknowledged from the National Natural Sciences Foundation of China (21235006), the Science and Technology Commission of Shanghai Municipality (12JG0500200), the Creative Research Group Project by NSFC (2132106), the National Key Scientific Instrument and Equipment Development Project (2012YQ120044), the China State Key Basic Research Program Grant (2013CB911202, 2012CB910601 and 2012CB-910101), the Analytical Method Innovation Program of MOST (2012M030900), and the Knowledge Innovation program of DICP to H.F.Z.

语种：英文

外文关键词：core-shell structures; magnetic properties; metal-organic frameworks; nanoparticles; peptides

摘要：Facile preparation of core-shell magnetic metal-organic framework nanospheres by a layer-by-layer approach is presented. The nanospheres have high surface area (285.89 cm(2)g(-1)), large pore volume (0.18 cm(3)g(-1)), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g(-1)), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum.