文献类型：期刊文献

英文题名：Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

作者：Lu, Wanying[1];Zhu, Guoliang[1];Yuan, Weize[1];Han, Zhaoxi[1];Dai, Huanqin[2];Basiony, Mostafa[1];Zhang, Lixin[1];Liu, Xueting[1];Hsiang, Tom[3];Zhang, Jingyu[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China;[3]Univ Guelph, Sch Environm Sci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada

年份：2021

卷号：6

期号：4

起止页码：446

外文期刊名：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000751765600004)】；

基金：This work was supported by the National Key Research and Development Program of China (2020YFA0907200, 2019YFA0906200, and 2020YFA0907800), the National Natural Science Foundation of China (21877038, 21907031, 21977029, 31720103901, and 81903529), Shanghai Rising-Star Program (20QA1402800), the Open Project Funding of the State Key Laboratory of Bioreactor Engineering, and the 111 Project (B18022). Discovery and isolation of F. proliferatum strain 13294 was supported by the Natural Sciences and Engineering Research Council of Canada funding to T. Hsiang.

语种：英文

外文关键词：Pathogenic fungus; Aliphatic unsaturated alcohols; Antibacterial; Natural products

摘要：Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1-3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 mu M).