文献类型：期刊文献

中文题名：多取代烯烃的Z∶E高选择性合成制备

英文题名：Z∶E Selective Preparation of Disubstituted Internal Alkenes and Trisubstituted Alkenes

作者：郭萍[1];周勇[1];赵杰[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2023

卷号：43

期号：3

起止页码：855

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000952559300004)】；北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

语种：中文

中文关键词：双取代内烯烃;三取代烯烃;Z∶E选择性

外文关键词：disubstituted internal olefins;trisubstituted olefins;Z∶E selectivity

摘要：烯烃是工业生产和药物合成中最常见的原料之一,关于烯烃制备方法的报道层出不穷.由于Z-构型烯烃与E-构型烯烃在理化性质和生物活性等方面存在很大的差异,所以烯烃结构的Z∶E构型控制是合成方法学的热点之一.综述了烯烃的立体选择性合成方法,着重总结了双取代内烯烃和三取代烯烃的Z∶E构型的选择性制备.以Z∶E选择性为主要分类标准,解读了Wittig反应、取代烷烃消除反应、烯烃异构化反应、烯烃复分解反应、烯烃偶联反应、炔烃加成反应的相关报道,并比较详细地描述了这些合成方法中的催化剂种类和Z∶E选择性的控制因素.
Olefin is one of the most important bulk chemicals in industry as well as commonly used starting materials in pharmaceutical field.Since Z-olefins and E-olefins exhibit great differences in physicochemical properties and biological activities,the Z∶E configuration control has been playing important roles in olefin preparation.The selective synthetic methods of Z∶E configurations of disubstituted inner alkenes and trisubstituted alkenes are reviewed,including the Wittig reaction,substituted alkane elimination reaction,olefin isomerization reaction,olefin metathesis,olefin coupling reaction,and alkyne addition reaction.The catalyst types and controlling factors of Z∶E selectivity in these synthetic examples are described in detail.