文献类型：期刊文献

英文题名：Multi-Stimuli-Responsive Amphiphilic Assemblies through Simple Postpolymerization Modifications

作者：Liu, Xiaochi[1,2];Hu, Ding[2];Jiang, Ziwen[2];Zhuang, Jiaming[2];Xu, Yisheng[1];Guo, Xuhong[1];Thayumanavan, S.[2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

年份：2016

卷号：49

期号：17

起止页码：6186

外文期刊名：MACROMOLECULES

收录：;EI(收录号：20163802814898);WOS:【SCI-EXPANDED(收录号:WOS:000383318300004)】；

基金：The work is supported by the U.S. Army Research Office (W911NF-15-1-0568) to S.T. X.L. gratefully acknowledges the support from the China Scholarship Council.

语种：英文

外文关键词：Functional polymers - Scaffolds (biology)

摘要：A strategy to construct different stimuli responsive polymers from postpolymerization modifications of a single polymer scaffold via thiol disulfide exchange has been developed. Here, we report on a random copolymer that enables the design and syntheses of a series of dual or multi stimuli-responsive nanoassemblies using a simple postpolymerization modification step. The reactive functional group involves a side chain monopyridyl disulfide unit, which rapidly and quantitatively reacts with various thiols under mild conditions. Independent and concurrent incorporation of physical, chemical, or biologically responsive properties have been demonstrated. We envision that this strategy may open up opportunities to simplify the synthesis of multifunctional polymers with broad implications in a variety of biological applications.