文献类型：期刊文献

英文题名：Relay transesterification strategy for direct synthesis of high-purity glycolide from methyl glycolate

作者：Xu, Xiaofeng[1,2];Zhang, Dai[1];Wang, Yifei[2,3];Cao, Yueqiang[1];Li, Wei[4];Zhou, Jinghong[1,2];Zhou, Xinggui[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn & Low Carbon Technol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Resources & Environm Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Coal Liquificat Gasificat & Utilizat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：19

期号：9

外文期刊名：FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING

收录：;EI(收录号：20253419021448);WOS:【SCI-EXPANDED(收录号:WOS:001551711300001)】；

基金：This work was financially supported by the Natural Science Foundation of China (Grant No. 22478106).

语种：英文

外文关键词：glycolide; transesterification; high-boiling-point alcohol; sustainable chemistry; bioplastics

摘要：High-purity glycolide is a key monomer for the synthesis of biodegradable polyglycolic acid. Here, we report a relay transesterification strategy for synthesizing high-purity glycolide directly from methyl glycolate, by using behenyl alcohol as a recyclable transesterification agent. This strategy achieves an average purity of 99.3% for glycolide without forming oligomers, and thus can avoid the energy-intensive purification required in the conventional route. Mechanistic studies indicate that methyl glycolate is first converted into behenyl glycolate via hetero-intermolecular transesterification during the relay transesterification process, and then the behenyl glycolate undergoes a homo-intermolecular transesterification to form behenyl dimer glycolate, which then undergoes intramolecular backbiting transesterification to yield glycolide and behenyl alcohol.