文献类型：会议论文

英文题名：Crystallization of Bovine Insulin on a Flow-free Droplet-based Platform

作者：Chen, Fengjuan[1];Du, Guanru[1];Yin, Di[1];Yin, Ruixue[1];Zhang, Hongbo[1];Zhang, Wenjun[1,2];Yang, Shih-Mo[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Res Ctr, Shanghai, Peoples R China;[2]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK, Canada

会议论文集：International Conference on Advances in Materials, Machinery, Electronics (AMME)

会议日期：FEB 25-26, 2017

会议地点：Wuhan, PEOPLES R CHINA

语种：英文

摘要：Crystallization is an important process in the pharmaceutical manufacturing industry. In this work, we report a study to create the zinc-free crystals of bovine insulin on a flow-free droplet-based platform we previously developed. The benefit of this platform is its promise to create a single type of crystals under a simpler and more stable environment and with a high throughput. The experimental result shows that the bovine insulin forms a rhombic dodecahedra shape and the coefficient variation (CV) in the size of crystals is less than 5%. These results are very promising for the insulin production.