文献类型：专利

中文题名：Ionic liquid chiral stationary phase and valsartan optical antimer separating method

作者：柯燕雄[1];赵见超[1];吴海波[1];王东强[1];陈龙[1];吴海霞[1];杜亚军[1];韦志深[1];程玲平[1];

机构：[1]华东理工大学;

专利类型：发明专利

申请号：CN201610231276

申请日：20160414

申请人地址：200237 上海市徐汇区梅陇路130号

公开日：20180522

代理人：翟羽;曾人泉

代理机构：上海翼胜专利商标事务所(普通合伙) 31218;上海翼胜专利商标事务所(普通合伙) 31218

语种：中文

摘要：Abstract：The invention discloses an ionic liquid chiral stationary phase. The ionic liquid chiral stationary phase is composed of an L-proline derivative module, an anion exchanger module formed by N-vinyl imidazole, and a mercaptopropyl silica gel module. The molecular structural formula of the ionic liquid chiral stationary phase is shown in the description, wherein R1 represents hydrogen, fat alkane group, naphthene alkyl, aryl containing substituent group or not, aralkyl, naphthyl and anthryl, and Y is any kind of anion. A method for separating valsartan optical antimers with the ionic liquid chiral stationary phase comprises the steps of 1, preparing a mobile phase; 2, dissolving the valsartan optical antimers with the mobile phase to obtain to-be-separated antimer solution; 3, adopting the ionic liquid chiral stationary phase with the formula I; 4, conducting chromatographic column separation on the to-be-separated valsartan antimer solution with the ionic liquid chiral stationary phase, conducting detection under the 254 nm ultraviolet detection condition, and recording a chromatogram. The ionic liquid chiral stationary phase and the valsartan optical antimer separating method solve the problem of small sample loading quantity caused by poor dissolution of the mobile phase of valsartan during chromatography preparation, and have the chiral chromatography preparation potential.