文献类型：期刊文献

中文题名：大麻二酚纳米结构脂质载体的制备及其性质研究

英文题名：Preparation and Properties of Cannabidiol Loaded Nanostructured Lipid Carrier

作者：秦尧[1];张新蕾[1];韩鑫桐[2];邹爱华[2,1]

机构：[1]华东理工大学化学与分子工程学院,上海200237;[2]上海师范大学化学与材料科学学院,上海200237

年份：2022

卷号：85

期号：7

起止页码：845

中文期刊名：化学通报

外文期刊名：Chemistry

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金项目(21872051)资助。

语种：中文

中文关键词：大麻二酚;纳米结构脂质载体;高压均质;缓释

外文关键词：Cannabidiol;Nanostructured lipid carrier;High-pressure homogenization;Sustained release

摘要：通过高压均质法制备包载大麻二酚(CBD)的纳米结构脂质载体(CBD-NLC),并考察其载药量、包封率、平均粒径、Zeta电位、长期储存稳定性等物理化学性质,筛选获得CBD-NLC最佳配方。在优化条件下制备的CBD-NLC平均粒径为163.7±1.3nm,多分散性指数(PDI)为0.14±0.02,包封率和载药量分别为95.5±1.0%和9.8±0.1%。通过透射电镜、傅里叶变换红外光谱、差示量热扫描、X射线衍射对CBD-NLC进行表征,结果表明,CBD被很好地负载在NLC中,CBD-NLC主要为球形结构。与文献报道相比,纳米结构脂质载体能够包载CBD,具有较好的载药量和包封率,可解决CBD的溶解性及稳定性问题,提高CBD的有效利用度。制备的CBD-NLC可用去离子水以任意比例稀释,具有良好的稳定性,便于其在医药产品中的应用。
CBD-NLC(cannabidiol(CBD) loaded nanostructured lipid carrier(NLC)) was prepared by high pressure homogenization method. Its optimum formulation was determined by the results of drug loading, encapsulation efficiency, average particle size, Zeta potential, long-term storage stability and etc. DLS results showed that the values of the average particle size and the polydispersity index(PDI) for the obtained CBD-NLC prepared under the optimized conditions were 163.7±1.3 nm and 0.14±0.02, respectively. And the values of the encapsulation efficiency and drug loading for the CBD-NLC were 95.5±1.0% and 9.8±0.1%, respectively. The CBD-NLC nanoparticles were further characterized by TEM, FTIR, PSC and XRD. The results indicated that CBD was successfully loaded in NLC, and most of CBD-NLC particles have the spherical shape. Compared with references, the NLC can encapsulate CBD with better drug loading and encapsulation efficiency, which can improve the solubility and stability problems of CBD, and also for the effective utilization of CBD. The CBD-NLC has good stability, and can be diluted with deionized water in any proportion, which is convenient for its application in pharmaceutical products.