文献类型：期刊文献

英文题名：Cu2-xS Nanocrystals Cross-Linked with Chlorin e6-Functionalized Polyethylenimine for Synergistic Photodynamic and Photothermal Therapy of Cancer

作者：Xiang, Huijing[1,2];Xue, Fengfeng[3,4];Yi, Tao[3,4];Tham, Huijun Phoebe[1];Liu, Jin-Gang[2];Zhao, Yanli[1,5]

机构：[1]Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China;[4]Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, 220 Handan Rd, Shanghai 200433, Peoples R China;[5]Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore

年份：2018

卷号：10

期号：19

起止页码：16344

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20181905173997);WOS:【SCI-EXPANDED(收录号:WOS:000432753800014)】；

基金：We are grateful for the financial support from the National Nature Science Foundation of China (Nos. 21571062, 21628401, and 21671043), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the Fundamental Research Funds for the Central Universities (No. 222201717003), and the Singapore National Research Foundation Investigatorship (No. NRF-NRFI2018-03). H.X. acknowledges the scholarship support from the Chinese Scholarship Council (No. 201506740024).

语种：英文

外文关键词：mitochondria-targeting multifunctional platform; photodynamic therapy; photothermal therapy; synergistic therapy

摘要：Achieving an integrated system for combinational therapy of cancer with enhanced efficacy is always a challenge. A multifunctional system (CCeT nanoparticles (NPs)) for a synergistic photodynamic and photothermal cancer therapy was successfully developed. This system is composed of Cu2-xS nanoclusters functionalized with chlorin e6 (Ce6)-conjugated branched polyethylenimine (PEI-Ce6) and mitochondria-targeting 3-(carboxypropyl)triphenylphosphonium bromide (TPP-COOH). The colocalization of the resulted CCeT NPs inside the mitochondria of cancer cells was proven. The CCeT NPs exhibited significant photodynamic therapy (PDT) efficacy due to efficient singlet oxygen (O-1(2)) generation triggered by a 630 nm laser. This system also showed excellent photothermal conversion capability upon the irradiation of 808 nm laser for photothermal therapy (PTT). In particular, the platform achieved nearly 100% inhibitory rate of the tumor growth in vivo through combinational PDT and PTT. Thus, the CCeT NPs could efficiently inhibit the tumor growth in vitro and in vivo by combinational PDT and PTT, offering synergistic therapeutic efficiency as compared to PTT or PDT alone.