文献类型：会议论文

中文题名：A simulation study of HPA model in the pain therapy

作者：Ying Du[1];Xinyu Wang[1];Weimin Bao[1];Jianzhong Su[2]

机构：[1]School of Science,East China University of Science and Technology;[2]Department of Mathematics, University of Texas at Arlington

会议论文集：第十八届全国非线性振动暨第十五届全国非线性动力学和运动稳定性学术会议（NVND2021）摘要集

会议日期：20210507

会议地点：中国广东广州

语种：英文

中文关键词：low back pain;pain trajectories;HPA;model;simulation

摘要：It is crucial of how pain transitions from acute to chronic for patients. Except the clinical approach, there is an increasingly need for a quantitative and predictive method to evaluate how pain trajectories are classified and how we can more effectively intervene. In this study, we use a computational hypothalamic-pituitary-adrenal(HPA) model to simulate pain trajectories. The result shows that different cortisol level can express various situation of acute, manic-style pain and intermittent pain pattern. Also, we can construct a good pain trajectory not only for an individual patient, but also for a group of patients. These results show the feasibility and the potential of developing such a mathematical model for patient evaluations.