文献类型：期刊文献

英文题名：Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration

作者：Liu, Shi[1];Han, Zhengzhe[2,3];Zhang, Dapeng[1];Li, Xianglong[1];Cao, Yuanyuan[1];Huang, Jinghuan[2,3];Li, Yongsheng[1,4]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn,Key Lab Ultrafine Mat,Minist Ed, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China;[3]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Inst Microsurg Extrem, 600 Yishan Rd, Shanghai 200233, Peoples R China;[4]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2023

卷号：26

起止页码：1

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000955094200001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2022YFC2403203) , the National Natural Science Foundation of China (Nos. 51972112, 82202695, and 52172279) , Basic Research Program of Shanghai (21JC1406003 and 19JC1411700) , Leading Talents in Shanghai in 2018, Shanghai Rising Star Program (21QA1402200) , the Natural Science Foundation of Shanghai (21ZR1416600) , and the 111 project (B14018) .

语种：英文

外文关键词：Parathyroid hormone; Dual -mode release; Thermosensitive hydrogel; Angiogenesis; Bone regeneration

摘要：Osteogenesis, osteoclastogenesis, and angiogenesis play crucial roles in bone regeneration. Parathyroid hormone (PTH), an FDA-approved drug with pro-osteogenic, pro-osteoclastogenic and proangiogenic capabilities, has been employed for clinical osteoporosis treatment through systemic intermittent administration. However, the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate carriers. Though several scaffolds have been developed to deliver PTH, they suffer from the weak-nesses such as uncontrollable PTH release, insufficient porous structure and low mechanical strength. Herein, a novel kind of NIR-activable scaffold (CBP/MBGS/PTHrP-2) with dual-mode PTHrP-2 (a PTH derivative) release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regen-eration, which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass (MBG) into the N-hydroxymethylacrylamide-modified, photothermal agent-doped, poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly process. Upon on/off NIR irradiation, the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG mesopores. Such NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone remodeling. In vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of rats. This work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration.