文献类型：期刊文献

英文题名：Naturally Occurring Polyphenolic Glucosidase Inhibitors

作者：Yang, You[1];Lian, Gaoyan[2];Yu, Biao[2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：55

期号：3-4

起止页码：268

外文期刊名：ISRAEL JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000352801400004)】；

基金：Financial support from the Ministry of Science and Technology of China (2012ZX09502-002) and the National Natural Science Foundation of China (21432012).

语种：英文

外文关键词：diabetes; flavonoid; inhibitors; metabolism; polyphenol

摘要：Polyphenols, which are abundantly distributed in plants such as fruits, vegetables, and tea, constitute a large group of aromatic compounds, mainly including phenolic acids and flavonoids. These natural metabolites have been demonstrated to possess a wide range of biological activities associated with health benefits, including the alpha-glucosidase inhibitory activity. In contrast to the classical alpha-glucosidase inhibitors, e.g., aza/imino sugars, polyphenols serve as a new type of alpha-glucosidase inhibitor with different, yet unknown, mechanisms of action, which could lead to novel dietary supplements and therapeutic agents for the prevention and treatment of metabolic disorders. In this review, we report a collection of 137 naturally occurring phenolic acids and flavonoids with alpha-glucosidase inhibitory activities.