文献类型：期刊文献

英文题名：99mTc-conjugated manganese-based mesoporous silica nanoparticles for SPECT, pH-responsive MRI and anti-cancer drug delivery

作者：Gao, Hongbo[1,2];Liu, Xiaohang[1,2];Tang, Wei[1,2];Niu, Dechao[3];Zhou, Bingni[1,2];Zhang, Hua[4];Liu, Wei[1,2];Gu, Bingxin[2,5];Zhou, Xiaobao[6];Zheng, Yingying[2,5];Sun, Yiyun[2,5];Jia, Xiaobo[3];Zhou, Liangping[1,2]

机构：[1]Fudan Univ, Dept Radiol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China;[2]Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai 200032, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Lab Low Dimens Mat Chem Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[4]Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China;[5]Fudan Univ, Shanghai Canc Ctr, Dept Nucl Med, Shanghai 200032, Peoples R China;[6]Shanghai Normal Univ, Coll Life & Environm Sci, Minist Educ, Key Lab Resource Chem, Shanghai 200234, Peoples R China

年份：2016

卷号：8

期号：47

起止页码：19573

外文期刊名：NANOSCALE

收录：;EI(收录号：20164903101957);WOS:【SCI-EXPANDED(收录号:WOS:000390095400012)】；

语种：英文

外文关键词：Controlled drug delivery - Manganese oxide - Particle beams - Tumors - Diseases - Single photon emission computed tomography - Mesoporous materials - Nanoprobes - Silica nanoparticles - Targeted drug delivery

摘要：In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 (Tc-99m) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnOx-MSNs) for use in SPECT-MRI dual-modal imaging. The radiolabelling yield was as high as 99.1 +/- 0.6%, and the r(1) value of the nanoprobes was able to reach 6.60 mM(-1) s(-1) due to the pH-responsive properties of the MnOx-MSNs. The high-performance SPECT-MRI dual-modal imaging was confirmed in vivo in tumour-bearing mice, which could also provide semi-quantitative information for tumour detection. Importantly, these nanoprobes can deliver anti-cancer drugs in cancer therapy due to their unique mesoporous structures. Thus, nanotheranostics combining dual-modal imaging with anticancer therapeutic properties were achieved.