文献类型：期刊文献

英文题名：Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens

作者：Zhu, Xiaojing[1];Mao, Yue[1];Guo, Miaomiao[2];Yu, Haiyuan[1];Hao, Liling[1];Hua, Qiang[1];Lu, Zhi[3];Hong, Minhua[3];An, Faliang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Beijing Technol & Business Univ, Key Lab Cosmet, 33 Fucheng Rd, Beijing 100048, Peoples R China;[3]Shanghai Inoherb Cosmet Co Ltd, Technol Ctr, 121 Chengyin Rd, Shanghai 200083, Peoples R China

年份：2020

卷号：130

期号：5

起止页码：457

外文期刊名：JOURNAL OF BIOSCIENCE AND BIOENGINEERING

收录：;EI(收录号：20203209008158);WOS:【SCI-EXPANDED(收录号:WOS:000615273200003)】；

基金：This work was funded by the National Key R&D Program of China (2018YFC1706200), Shanghai Baoshan Government Industry University Institute collaboration (17-C-1), and the Open Research Fund Program of Key Laboratory of Cosmetic (Beijing Technology and Business University), China National Light Industry (KLC-2019-ZD2).

语种：英文

外文关键词：Acne; Inflammation; Plant fermentation; Scutellaria baicalensis extract; Wogonin

摘要：Inflammatory responses stimulated by Propionibacterium acnes have been shown to be major etiological factors in the pathogenesis of acne. Scutellaria baicalensis, a popular traditional Chinese medicine, has been widely shown to have anti-inflammatory effects. In this study, primary component analysis and primary effective component analysis were conducted. The results showed that wogonin (1.15 mg/g S. baicalensis extract) possessed better anti-acne effects than wogonoside (8.71 mg/g S. baicalensis extract) in inhibiting the up-regulation of IL-1 beta and IL-8 level caused by P. acnes via inactivation of the MAPK and NF-kappa B signaling pathways. To enhance the anti-acne effects of S. baicalensis extract, an environmentally friendly and healthy plant fermentation strategy was used to efficiently convert glycoside-type constituents into bioactive aglycone. S. baicalensis extract was fermented by symbiotic fungus Penicillium decumbens f3-1 to transform wogonoside into wogonin with a conversion rate of 91.0% after 4 days. Fermented S. baicalensis extract (FSE) showed higher potential anti-acne effects than non-fermented S. baicalensis extract (NSE) by inhibiting the upregulation of IL-1 beta and IL-8. Thus, P. decumbens-fermented S. baicalensis Extract may be used for developing new anti-acne cosmetic ingredients. (C) 2020, The Society for Biotechnology, Japan. All rights reserved.