文献类型：专利

英文题名：Enzyme method separation process for racemic ketoprofen - comprising Lipase OF crude enzyme as an enzymatic hydrolysis reaction catalyst

作者：XU J;LIU Y;YANG S

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN1215085-A

申请日：1998-10-12

公开日：1999-04-28

语种：英文

收录：DERWENT

摘要：An enzymatic resolution process of producing recemic ketoprofen, is new. The invention uses the Lipase OF crude enzyme produced by Japan Meito Sangyo Co., Ltd. as an enzymatic hydrolysis reaction catalyst to directly make resolution of ketoprofen receme, and implement the enzymatic resolution reaction under the condition of high acidity and in the presence of surfactant, e.g. Tween-80. ADVANTAGE - The process produces (S)-ketoprofen and (R)-ketoprofen with high optical purity and can greatly reduce production costs.