文献类型：期刊文献

英文题名：Preparation, degradation and in vitro release of ciprofloxacin-eluting ureteral stents for potential antibacterial application

作者：Ma, Xiaofei[1];Xiao, Yan[1];Xu, Heng[3];Lei, Kun[1];Lang, Meidong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat & Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Collaborat Innovat Ctr Petrochem New Mat, Anqing 246011, Anhui, Peoples R China

年份：2016

卷号：66

起止页码：92

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20162002397555);WOS:【SCI-EXPANDED(收录号:WOS:000377737000011)】；

基金：This work was supported by the National Natural Science Foundation of China (51103041, 21274039), Shanghai Scientific and Technological Innovation Project (14520720600), the Fundamental Research Funds for the Central Universities (WD1414007), 111 project (B14018) and Specialized Research Fund for the Doctoral Program of Higher Education (20130074110007). The authors acknowledged the kind help of Dr. Zhaoyang Ye, Zhimiao Xiong for cytotoxicity tests and Changlin Chen, Yunlong Sun for antibacterial experiments.

语种：英文

外文关键词：Ciprofloxacin lactate; Release mechanism; Ureteral stents; Degradation; Coating; Antibacterial; Cytotoxicity

摘要：Drug-eluting stents with biodegradable polymers as reservoirs have shown great potential in the application of interventional therapy due to their capability of local drug delivery. Herein, poly(L-lactide-co-epsilon-caprolactone) (PLCL) with three different compositions as carriers for ciprofloxacin lactate (UP) was coated on ureteral stents by the dipping method. To simulate a body environment, degradation behavior of PLCL as both the bulk film and the stent coating was evaluated in artificial urine (AU, pH 6.20) respectively at 37 degrees C for 120 days by tracing their weight/Mn loss, water absorption and surface morphologies. Furthermore, the release profile of the eluting drug CIP on each stent exhibited a three-stage pattern, which was greatly affected by the degradation behavior of PLCL except for the burst stage. Interestingly, the degradation results on both macroscopic and molecular level indicated that the release mechanism at stage I was mainly controlled by chain scission instead of the weight loss or morphological changes of the coatings. While for stage II, the release profile was dominated by erosion resulting from the hydrolysis reaction autocatalyzed by acidic degradation residues. In addition, ciprofloxacin-loaded coatings displayed a significant bacterial resistance against E. coli and S. aureus without obvious cytotoxicity to Human foreskin fibroblasts (HFFs). Our results suggested that PLCL copolymers with tunable degradation rate as carriers for ciprofloxacin lactate could be used as a promising long-term antibacterial coating for ureteral stents. (C) 2016 Elsevier B.V. All rights reserved.