文献类型：期刊文献

英文题名：Self-Assembled Poly(sarcosine) Functionalized Host Defense Peptide-Mimicking Poly-β-Peptides for Combating Drug-Resistant Fungal Infection

作者：Xie, Jiayang[1];Liu, Zhefeng[1];Zhou, Min[1,2];Luo, Zhengjie[1];Liu, Longqiang[2];Xiao, Ximian[2];Jiang, Weinan[3];Hu, Weilong[2];Wu, Yueming[2];Liu, Runhui[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat,Shanghai Frontiers Sci Ctr, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & En, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China

年份：2025

卷号：35

期号：42

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20251918373535);WOS:【SCI-EXPANDED(收录号:WOS:001481693900001)】；

基金：This work was financially supported by the Chinese Academy of Sciences Project for Young Scientists in Basic Research (No. YSBR-111), National Key Research and Development Program of China (No. 2022YFC2303100), National Natural Science Foundation of China (Nos. T2325010, 22075078, 22305082, 52203162, and 52361165622), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission). The authors thank the Analysis and Testing Center of the School of Chemical Engineering, East China University of Science and Technology for the support. The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization for studies reviewed in this manuscript.

语种：英文

外文关键词：antifungal; host defense peptide mimic; poly(sarcosine) functionalized; poly-beta-peptides; self-assembly

摘要：The scarcity of clinically available antifungal drugs, coupled with frequent side effects and the accelerating emergence of fungal drug resistance, underscores the pressing demand for novel antifungal drugs. Host defense peptide (HDP) assemblies are one of the ideal alternatives to antifungal drugs due to the distinctive advantages of nanostructures, but still face challenges in terms of in vivo stability, biosafety, and facile synthesis. Poly-beta-peptides are a class of polypeptide mimics that possess excellent biocompatibility and resistance to proteolysis, however, their antimicrobial assemblies have yet to be explored. Herein, the advantages of poly-beta-peptide and poly(sarcosine) are integrated to design self-assembled poly(sarcosine) functionalized HDP mimics, while establishing a one-pot, open-vessel synthesis method for block-like poly-beta-peptide. The synthesized multifunctional poly-beta-peptide assemblies exhibit potent and highly selective antifungal activity against drug-resistant fungi with excellent biosafety, effectively eradicate mature biofilms, and demonstrate potent in vivo antifungal efficacy. Notably, fungi are insusceptible to acquire resistance against the assemblies owing to the antifungal mechanisms associated with organelle destruction and reactive oxygen species. These results demonstrate the potential of the strategy in developing self-assembled HDP mimics and combating drug-resistant fungal infections.