文献类型：期刊文献

中文题名：Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold: Synthesis and bioactivity

英文题名：Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold: Synthesis and bioactivity

作者：Qing-Shan Du[1];Yan-Xia Shi[2];Peng-Fei Li[1];Zhen-Jiang Zhao[1];Wei-Ping Zhu[1];Xu-Hong Qian[1];Bao-Ju Li[2];Yu-Fang Xu[1]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology;[2]Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences

年份：2013

卷号：24

期号：11

起止页码：967

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2013_2014】；PubMed;

基金：financially supported by the National Basic Research Program of China (973 Program, No. 2010CB126100);the National High Technology Research and Development Program of China (863 Program, No. 2011AA10A207);the China 111 Project (No. B07023);the Fundamental Research Funds for the Central Universities.

语种：英文

中文关键词：Thieno[2;3-d]-1;2;3-thiadiazole-6-carboxylate derivatives Plant activator Systemic acquired resistance

外文关键词：Thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate derivatives Plant activator Systemic acquired resistance

摘要：The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied.The structures of the novel compounds were identifed by1H NMR,19F NMR and HRMS.The in vivo bioassay showed that these novel compounds had good effcacy against seven plant diseases.Especially,compounds 1a and 1c were more potent than the commercialized plant activator BTH.Almost no fungicidal activity was observed for the active compounds in the in vitro assay,which matched the requirements as plant activators.
The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied.The structures of the novel compounds were identifed by1H NMR,19F NMR and HRMS.The in vivo bioassay showed that these novel compounds had good effcacy against seven plant diseases.Especially,compounds 1a and 1c were more potent than the commercialized plant activator BTH.Almost no fungicidal activity was observed for the active compounds in the in vitro assay,which matched the requirements as plant activators.