文献类型：期刊文献

英文题名：A novel human derived cell-penetrating peptide in drug delivery

作者：Zhao, Jian[1];Gao, Peng[1];Xiao, Wei[1];Fan, Li-Qiang[1];Wang, Fu-Jun[2];Li, Su-Xia[1];Liu, Jian-Wen[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Zhejiang Reachall Pharmaceut Co Ltd, Zhejiang 322100, Peoples R China

年份：2011

卷号：38

期号：4

起止页码：2649

外文期刊名：MOLECULAR BIOLOGY REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289257100054)】；

语种：英文

外文关键词：hC-SOD3; Human cell-penetrating peptide; Apoptin; Drug delivery

摘要：Cell-penetrating peptides can carry a variety of biologically active molecules into cells. Here we have identified a novel CPP derived from the C-terminus of human extracellular superoxide dismutase (hC-SOD3) which was shown to be located throughout in the cytoplasm and nucleus by fluorescence microscopy investigation. Furthermore, when apoptin fused to hC-SOD3, it was translocated efficiently into HeLa cells resulting in antitumor activities. This study shows that hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration.