文献类型：期刊文献

英文题名：Visible sonodynamic therapy targeting blood vessels using rapid-functionalized carbon nanostructure

作者：Hao, Liangshi[1];He, Yupei[2];Wang, Chengbang[1];Yu, Chen[3];Sha, Wenjie[2];Yang, Siwei[4];Wei, Ziwei[1];Hao, Changning[1];Chen, Zhuo[2];Xu, Bin[1]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Urol, Sch Med, Shanghai 200011, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Beijing Univ Technol, Coll Environm Sci & Engn, Beijing 100124, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China

年份：2025

卷号：46

外文期刊名：APPLIED MATERIALS TODAY

收录：;EI(收录号：20253419013147);WOS:【SCI-EXPANDED(收录号:WOS:001584123100001)】；

基金：Liangshi Hao and Yupei He contributed equally to this work. All animal experiments were conducted following protocols approved by the Institutional Animal Care and Use Committee of the Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine and East China University of Science and Technology. This work was supported by National Natural Science Foundation of China (12174289) ; and the Fundamental Research Funds for the Central Universities (YG2025QNB05) ; and the Fundamental Research Funds for the Central Universities (project number YG2025QNB05) and Shanghai Oriental Talents-Excellent Young Academic Leader; and "100 Academic Doctors" of Shanghai Jiao Tong University School of Medicine (2022sbr-xb) .

语种：英文

外文关键词：Sonosensitizer; Rapid functionalization; Anti-angiogenesis; Zebrafish; Quantum dots

摘要：Angiogenesis imbalance can cause severe diseases such as malignant tumors, and inhibition of angiogenesis may suppress such imbalance. Endoglin (CD105) which is associated with angiogenesis serves as the prime vascular target for antiangiogenetic therapy. Notably, carbon nanostructures with good biocompatibility and excellent 1O2 generation capability can be used to construct agents to inhibit angiogenesis. Compared to photodynamic therapy, the high tissue penetration depth and guaranteed safety make sonodynamic therapy suitable for inhibition of angiogenesis. Herein, the high-specificity CD105 antibody-functionalized C3N quantum dots (Af-C3N QDs) have been synthesized through light induction within 40 min and without using excess chemicals. The highbiosafety Af-C3N QDs combined with ultrasonic treatment can largely enhance the efficiency in inhibiting the angiogenesis of zebrafish. This finding not only provides important theoretical support for the application of rapidly functionalized carbon nanostructures in sonodynamic therapy (SDT) but also lays a solid foundation for understanding the structure-dependent SDT enhancement mechanism, potentially promoting the further development and clinical application of sonodynamic therapy.