文献类型：期刊文献

英文题名：Advances in the antimicrobial treatment of osteomyelitis

作者：Zhong, Chao[1];Wu, Yueming[1];Lin, Haodong[2,3];Liu, Runhui[1,4,5]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped Surg, Sch Med, Shanghai 200080, Peoples R China;[3]Shanghai Gen Hosp, Jiading Branch, Shanghai 201803, Peoples R China;[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Shenzhen Res Inst, Shenzhen 518063, Peoples R China

年份：2023

卷号：249

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20224713147862);WOS:【SCI-EXPANDED(收录号:WOS:000900034200001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 22075078, 21861162010), the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), Program of Shanghai Academic/Technology Research Leader (20XD1421400), the China Postdoctoral Science Foundation (2022M711150, 2021M701198), China National Postdoctoral Program for Innovative Talents (BX20220108), Free Exploring Basic Research Project at Shenzhen Research Institute of ECUST (2021Szvup042), Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28).

语种：英文

外文关键词：Osteomyelitis; Antimicrobial agent therapy; Physical therapy; Immunotherapy

摘要：Osteomyelitis is a major complication of orthopedic diseases with high recurrence and morbidity, along with long hospital stays and high medical costs. The conventional treatment of osteomyelitis involves surgical debridement followed by long-term and high-dose of systemic antibiotic therapy, which in many cases is not effective and can induces serious bacterial resistance. As an alternative strategy, local therapy has been devel-oped for treatment of osteomyelitis. In this review, we expound on the advances in the antimicrobial treatment of osteomyelitis including antimicrobial agent therapy, physical therapy and immunotherapy, which we hope to shed some light on future research of osteomyelitis treatment.