文献类型：期刊文献

中文题名：光控基因表达系统

英文题名：Light-regulated gene expression systems

作者：陈显军[1];左方婷[1];杨弋[1]

机构：[1]华东理工大学生物反应器工程国家重点实验室,上海200237

年份：2019

卷号：31

期号：4

起止页码：343

中文期刊名：生命科学

外文期刊名：Chinese Bulletin of Life Sciences

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家重点研发计划(2017YFA050400);国家自然科学基金项目(31225008;31470833;31600688)

语种：中文

中文关键词：光遗传学;基因表达;细胞和基因治疗;代谢工程;合成生物学

外文关键词：optogenetics;gene expression;cell and gene based therapy;metabolic engineering;synthetic biology

摘要：基因表达是生命的最本质特征之一,基因表达的调控对于研究生物体的各种生命现象具有至关重要的意义。长期以来,科学家们一直在追求可以在时间、空间上调控基因表达的技术。光遗传学的出现与快速发展已经允许人们以前所未有的时空精度调控基因表达。该文将介绍光控基因表达系统的研究进展,以及它们在疾病治疗、代谢工程以及合成生物学领域的应用;同时,探讨光控基因表达系统未来在各种应用中的意义和挑战。
Gene expression is one of the most essential characteristics of life. Regulation of gene expression plays an essential role in studying diverse processes of living life. During these years, scientists have been perusing a technology allowing spatiotemporal control of gene expression. The emergency and development of optogenetics allow precise spatiotemporal control of gene expression. In this review, we describe the advances in light-regulated gene expression systems, as well as their applications in disease therapy, metabolic engineering and synthetic biology. Meanwhile, we discuss the significance and challenge of using the light-regulated gene expression systems for diverse applications.