文献类型：期刊文献

英文题名：Fabrication of uniform hollow mesoporous silica spheres and ellipsoids of tunable size through a facile hard-templating route

作者：Zhao, Wenru[1];Lang, Meidong[1];Li, Yongsheng[1];Li, Liang[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2009

卷号：19

期号：18

起止页码：2778

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY

收录：;EI(收录号：20092012081564);WOS:【SCI-EXPANDED(收录号:WOS:000265740600019)】；

基金：This work was financially supported by the National Natural Science Foundation of China ( Grant No. 20571081, 20633090), the National Hi-Tech Project of China ( Grant No. 2007AA03Z317), Chinese Academy of Sciences ( Grant No. KJCX2.YW.M02, KGCX2-YW-210) and the China Postdoctoral Science Foundation ( Grant No. 20070410697).

语种：英文

外文关键词：Spheres - Mesoporous materials - Fabrication - Silica - Drug products - Hematite

摘要：A facile hard-templating route has been successfully developed to fabricate uniform hollow mesoporous silica spheres and ellipsoids by using hematite as hard template. The outer diameter of the spherical mesoporous silica particles can be well adjusted in a sub-micrometric range (typically around 100-200nm) by selecting suitable hematite particles as core templates. The thickness of the mesoporous shell can be tuned independently at around 10nm by tailoring the amount of tetraethoxysilane and n-octadecyltrimethoxysilane mixture. Ellipsoidal hollow mesoporous silica particles are prepared as well for the first time when spindle shaped hematite particles are employed as core templates. In addition, these hollow mesoporous particles manifest high drug storage capacity (726 mg ibuprofen per gram) mainly and physically in the core part, hence justifying their promising applications as nanocarriers in drug delivery.