文献类型：期刊文献

英文题名：A general asymmetric route to enantio-enriched isoflavanes via an organocatalytic annulation of o-quinone methides and aldehydes

作者：Zhang, Jian[1];Zhang, Shuangzhan[1];Yang, Huixin[1];Zhou, Ding[1];Yu, Xueting[1];Wang, Wei[1,2];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2018

卷号：59

期号：25

起止页码：2407

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000434902200006)，CCR-EXPANDED(收录号:WOS:000434902200006)】；

基金：We thank the National Natural Science Foundation of China (21472048), the "Thousand Plan" Youth Program, and the Fundamental Research Funds for the Central Universities for financial support.

语种：英文

外文关键词：Isoflavanes; Asymmetric; Organocatalysis; o-Quinone methide

摘要：Reported herein is a general approach to optically active isoflavanes based on a chiral amine-catalyzed [4 + 2] asymmetric annulation of o-quinone methides and aldehydes. A number of naturally occurring isoflavanes, including equol, sativan, isosativan, vestitol and medicarpin, as well as isoflavane analogues were readily prepared with good to excellent enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.