文献类型：期刊文献

英文题名：Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes

作者：Fu, Shiyu[1];Sun, Changlei[1];Tao, Xinyi[1];Ren, Yuhong[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2012

卷号：26

期号：18

起止页码：1746

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000307927400018)】；

基金：Both authors contributed equally to this article. This work was supported by Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：anti-inflammatory activity; acne; cytokines; Chinese medicinal herbs

摘要：Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) from keratinocyte play important roles in initiating the inflammatory process of acne. They are used as major elements to evaluate the anti-inflammatory activity of drugs. In this study, various active constituents extracted from Chinese medicinal herbs were tested for their anti-inflammatory effects against P. acnes using ELISA. Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes. Excepting hesperidin, these active constituents presented dose-dependent inhibitory effects. Our studies showed that all of them exhibited low cytotoxicity at 5 mu g mL(-1) in tested cell lines, and even at 50 mu g mL(-1), in the cases of matrine, baicalin, ursolic acid and sodium danshensu. Based on the obtained results, it can be suggested that these active constituents are potential acne-mitigating candidates for cosmetic applications.