文献类型：期刊文献

英文题名：Preparation and Characterization of Size-Controlled Nanoparticles for High-Loading λ-Cyhalothrin Delivery through Flash Nanoprecipitation

作者：Chen, Kai[1,2];Fu, Zhinan[1];Wang, Mingwei[1];Lv, Yin[2];Wang, Chunxin[3];Shen, Yue[3];Wang, Yan[3];Cui, Haixin[3];Guo, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Shihezi 832000, Peoples R China;[3]Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China

年份：2018

卷号：66

期号：31

起止页码：8246

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20183005603302);WOS:【SCI-EXPANDED(收录号:WOS:000441476400005)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (21476143, 51773061, 31701825, and 5171101370), the Major National Scientific Research Program of China (2014CB932200), the National Key Research and Development Program of China (2016YFD0200500), and the Open Project of Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region (No. 2016BTRC006).

语种：英文

外文关键词：flash nanoprecipitation; nanosuspension; lambda-cyhalothrin; block polymer

摘要：Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of lambda-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEGPDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.