文献类型：期刊文献

英文题名：Eco-friendly synthesis of 3-etherified estrones

作者：Zheng, Dong-Qing[2];Jing, Yu[3];Zheng, Bing-Ying[3];Ye, Yun-Fei[2];Xu, Sheng[2];Tian, Wei-Sheng[1];Ma, Hai-Yan[2];Ding, Kai[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Lab Resource Chem, 100 Guiling Rd, Shanghai 200234, Peoples R China

年份：2016

卷号：72

期号：17

起止页码：2164

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000374424900011)，CCR-EXPANDED(收录号:WOS:000374424900011)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (No. 20902098 and No. U1362111)

语种：英文

外文关键词：Estrogen; Aromatization; Etherification; Eco-friendly

摘要：The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3 -secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material. (C) 2016 Elsevier Ltd. All rights reserved.