文献类型：期刊文献

英文题名：Wireless Bipolar Nanopore Electrode for Single Small Molecule Detection

作者：Gao, Rui;Ying, Yi-Lun[1];Hu, Yong-Xu;Li, Yuan-Jie;Long, Yi-Tao[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：89

期号：14

起止页码：7382

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20173003988415);WOS:【SCI-EXPANDED(收录号:WOS:000406085300016)】；

基金：This work was supported by the National Natural Science Foundation of China (21421004, 21327807, and 21505043) and the Fundamental Research Funds for the Central Universities (222201718001, 222201717003, and 222201714012). The authors would like to thank Center for Advanced Electronic Materials and Devices, Shanghai Jiao Tong University for providing the SEM characterization.

语种：英文

外文关键词：Metal coatings - Molecules - Electrodes - Finite element method

摘要：Solid-state nanopore-based techniques have become a promising strategy for diverse single molecule detections. Owing to the challenge in well and rapid fabrication of solid-state nanopores with the diameter less than 2 nm, small molecule detection is hard to be addressed by existing label-free nanopore methods. In this work, we for the first time propose a metal-coated wireless nanopore electrode (WNE) which offers a novel and generally accessible detection method for analyzing small molecules and ions at the single molecule/ion level. Here, a silver-coated WNE is developed as a proof-of-principle model which achieves the detection the self-generated H-2, the smallest known molecule, and Ag+ at single molecule/ion level by monitoring the enhanced ionic signatures. Under a bias potential of -800 mV, the WNE could accomplish the distinction of as low as 14 H-2 molecules and 28 Ag+ from one spike signal. The finite element simulation is introduced to suggest that the generation of H-2 at the orifice of the WNE results in the enhanced spike of ionic current. As a proof-of-concept experiment, the WNE is further utilized to directly detect Hg2+ from 100 pM to 100 nM by monitoring the frequency of the spike signals. This novel nanoelectrode provides a brand new label-free, ultrasensitive, and simple detection mechanism for various small molecules/ions detection, especially for redox analytes.