文献类型：期刊文献

英文题名：Electrocatalytic Oxidation of NADH on Graphene Oxide and Reduced Graphene Oxide Modified Screen-Printed Electrode

作者：Zhang, Lei[1];Li, Yang[1];Zhang, Li[1];Li, Da-Wei[1];Karpuzov, Dimitre[2];Long, Yi-Tao[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Univ Alberta, Alberta Ctr Surface Engn & Sci, Edmonton, AB T6G 2G6, Canada

年份：2011

卷号：6

期号：3

起止页码：819

外文期刊名：INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000287820500024)】；

基金：The authors greatly appreciate the funding support from the Ministry of Health of China (No. 2009ZX10004-301), the National Natural Science Foundation of China (21001004). YTL thanks the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning.

语种：英文

外文关键词：Graphene oxide; nicotinamide adenine dinucleotide; screen-printed electrode; biosensors; XPS

摘要：A facile method, Graphene Oxide (GO) modified electrochemically pre- anodized screen- printed carbon electrodes (SPCEs), was developed for the determination of nicotinamide adenine dinucleotide (NADH) in neutral aqueous solution. Compared with the bare SPCEs and the reduced Graphene Oxide (rGO) modified SPCEs (rGO/SPCEs), the GO/SPCEs exhibit greatly enhanced electrocatalytic oxidation toward NADH. The scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) provide the substantial evidence for the formation of edge- plane sites on the surface of SPCEs, rGO/SPCEs and GO/SPCEs. The GO/SPCEs show the excellent electrochemical character for the determination of NADH in the range from 0.8 to 500 mu M with a detection limit of 0.10 mu M. The formation of oxidation product NAD(+) was confirmed by in- situ UV- Vis spectroelectrochemistry. It shows a great promise for the design of the disposable amperometric biosensor for NADH.