文献类型：期刊文献

英文题名：Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions

作者：Chen, Ying[1];Moser, Michael A. J.[2];Luo, Yigang[2];Zhang, Wenjun[1,3];Zhang, Bing[4]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]Univ Saskatchewan, Dept Surg, Saskatoon, SK, Canada;[3]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK, Canada;[4]Shanghai Univ, Sch Mechatron Engn & Automat, Energy Based Tumor Ablat Lab, Shanghai 200444, Peoples R China

年份：2019

卷号：18

外文期刊名：TECHNOLOGY IN CANCER RESEARCH & TREATMENT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000484896600001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This article was supported in part by 111 Project (D18003) and National Natural Science Foundation of China (Grant No. 81801795).

语种：英文

外文关键词：irreversible electroporation; chemical enhancement; calcium electroporation; cytotoxic drugs; surfactants; cell microenvironment

摘要：Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablation technology that uses short high-voltage electrical pulses to enhance the permeability of tumor cell membranes and generate irreversible nano-sized structural defects or pores, thus leading to cell death. Irreversible electroporation has many advantages over thermal therapies due to its nonthermal mechanism: (1) reduced risk of injury to surrounding organs and (2) no "heat-sink" effect due to nearby blood vessels. However, so far, it has been difficult for irreversible electroporation to completely ablate large tumors (eg, >3 cm in diameter). In order to overcome this problem, many preclinical and clinical studies have been performed to improve the efficacy of IRE in the treatment of large size of tumors through a chemical perspective. Due to the distribution of electric field, irreversible electroporation region, reversible electroporation region, and intact region can be found in the treatment of irreversible electroporation. Thus, 2 types of chemical enhancements of irreversible electroporation were discussed in the article, such as the reversible electroporation region enhanced and the irreversible electroporation region enhanced. Specifically, the state-of-the-art results regarding the following approaches that have the potential to be used in the enhancement of irreversible electroporation were systematically reviewed in the article, including (1) combination with cytotoxic drugs, (2) calcium electroporation, (3) modification of cell membrane, and (4) modification of the tumor cell microenvironment. In the end, we concluded with 4 issues that should be addressed in the future for improving irreversible electroporation further in a chemical way.