文献类型：期刊文献

英文题名：Moldable and Removable Wound Dressing Based on Dynamic Covalent Cross-Linking of Thiol-Aldehyde Addition

作者：Hua, Yujie[1];Gan, Yibo[2,3];Li, Pei[2];Song, Lei[2];Shi, Chunmeng[3];Bao, Chunyan[1];Yang, Yi[1];Zhou, Qiang[2,4];Lin, Qiuning[1];Zhu, Linyong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Optogenet & Synthet Biol Interdisciplinary Res Ct, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Army Med Univ, Mil Med Univ 3, Southwest Hosp, Dept Orthoped, 29 Gaotanyan St, Chongqing 400038, Peoples R China;[3]Army Med Univ, Mil Med Univ 3, State Key Lab Trauma Burns & Combined Injury, Inst Rocket Force Med,Coll Prevent Med, 30 Gaotanyan St, Chongqing 400038, Peoples R China;[4]Chongqing Med Univ, Gener Hosp, Affiliated Hosp 3, Bone & Trauma Ctr, Chongqing 401120, Peoples R China

年份：2019

卷号：5

期号：8

起止页码：4048

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20193507378596);WOS:【SCI-EXPANDED(收录号:WOS:000480826400031)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grants 21774030, 21425311, and 81802165), Key Project of Military Medical Technology Innovation Program (SWH2017JCZD-02), Army Major Projects (AWS14C007), and University Innovation Team Building Program of Chongqing (CXTDG201602020).

语种：英文

外文关键词：dynamic covalent cross-linking; thiol-aldehyde addition; removable hydrogels; wound dressing

摘要：The development of a moldable and removable gel technique for wound dressing is becoming highly desirable. Herein, we describe a facile method to generate an adaptable and dissolvable network of PEG-thiols and aldehyde groups in oxidized dextran. The dynamic covalent chemistry of the thiol-aldehyde addition reaction provides hydrogels with typical rheological behavior and thus endows the hydrogels with an excellent adaptability for the initial operation of wound coverage. Upon addition of free thiol compounds, the dynamic covalent cross-linked hydrogels will dissolve via thiol-hemithioacetal exchange reaction. The successful application as a temporary dressing for scalded wounds indicated the hydrogels had both adaptability and dissolvability based on the thiol-aldehyde addition reaction, which is significant for biomedical areas.