文献类型：期刊文献

英文题名：Chemical and photochemical DNA "gears" reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels

作者：Liu, Xia[1];Zhang, Junji[2,3];Fadeev, Michael[1];Li, Ziyuan[2,3];Wulf, Verena[1];Tian, He[2,3];Willner, Itamar[1]

机构：[1]Hebrew Univ Jerusalem, Inst Chem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：10

期号：4

起止页码：1008

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20190506450970);WOS:【SCI-EXPANDED(收录号:WOS:000457342200002)】；

基金：This research was supported by the Israel Science Foundation (ISF 1613/16), the Minerva Center for Biohybrid Complex Systems, and the National Natural Science Foundation of China (21420102004), Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and the international cooperation program of Shanghai Science and Technology Committee (17520750100).

语种：英文

外文关键词：Stiffness - Biomolecules - Controlled drug delivery - Nucleic acids - Self-healing materials - Targeted drug delivery - Crosslinking - Esters - Ions - Azobenzene

摘要：A new class of stimuli-responsive DNA-based polyacrylamide hydrogels is described. They consist of glucosamine-boronate ester-crosslinked polyacrylamide chains being cooperatively bridged by stimuli-responsive nucleic acids. The triggered closure and dissociation of the stimuli-responsive units lead to switchable stiffness properties of the hydrogel. One hydrogel includes glucosamine-boronate esters and K+-ion-stabilized G-quadruplex units as cooperative crosslinkers. The hydrogel bridged by the two motifs reveals high stiffness, whereas the separation of the G-quadruplex bridges by 18-crown-6-ether yields a low stiffness hydrogel. By cyclic treatment of the hydrogel with K+-ions and 18-crown-6-ether, it is reversibly cycled between high and low stiffness states. The second system involves a photo-responsive hydrogel that reveals light-induced switchable stiffness functions. The polyacrylamide chains are cooperatively crosslinked by glucosamine-boronate esters and duplex nucleic acid bridges stabilized by trans-azobenzene intercalator units. The resulting hydrogel reveals high stiffness. Photoisomerization of the trans-azobenzene units to the cis-azobenzene states results in the separation of the duplex nucleic acid bridges and the formation of a low stiffness hydrogel. The control over the stiffness properties of the hydrogel matrices by means of K+-ions/crown ether or photoisomerizable trans-azobenzene/cis-azobenzene units is used to develop shape-memory, self-healing, and controlled drug-release hydrogel materials.