文献类型：期刊文献

英文题名：The Impact of Systems Biology on Bioprocessing

作者：Campbell, Kate[1];Xia, Jianye[1,2];Nielsen, Jens[1,3]

机构：[1]Chalmers Univ Technol, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[3]Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark

年份：2017

卷号：35

期号：12

起止页码：1156

外文期刊名：TRENDS IN BIOTECHNOLOGY

收录：;EI(收录号：20174104248977);WOS:【SCI-EXPANDED(收录号:WOS:000415306900007)】；

语种：英文

外文关键词：Creep - Plant shutdowns - Computational methods - Fossil fuels - Data handling - Genes - Learning systems - Information analysis - Digital storage - Physiology

摘要：Bioprocessing offers a sustainable and green approach to the production of chemicals. However, a bottleneck in introducing bioprocesses is cell factory development, which is costly and time-consuming. A systems biology approach can expedite cell factory design by using genome-wide analyses alongside mathematical modeling to characterize and predict cellular physiology. This approach can drive cycles of design, build, test, and learn implemented by metabolic engineers to optimize the cell factory performance. Streamlining of the design phase requires a clearer understanding of metabolism and its regulation, which can be achieved using quantitative and integrated omic characterization, alongside more advanced analytical methods. We discuss here the current impact of systems biology and challenges of closing the gap between bioprocessing and more traditional methods of chemical production.