文献类型：期刊文献

英文题名：Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance

作者：Ma, Pengcheng[1];Chen, Yuan[2];Shao, Ning[2];Zhang, Junyu[2];Wu, Yueming[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat,Minist Educ,Key Lab Ultrafine, Sch Mat Sci & Engn,Shanghai Frontiers Sci Ctr Opt, Shanghai 200237, Peoples R China

年份：2022

卷号：40

期号：24

起止页码：2947

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000876358900001)】；

基金：This research was supported by the National Natural Science Foundation of China (Nos. 22075078, 21861162010), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), the Fundamental Research Funds for the Central Universities (JKD01211520). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Antimicrobial polymer; Aquaculture; Peptides; Antibiotics; Biological activity

摘要：Comprehensive Summary The massive use of antibiotics in aquaculture and resulted antibacterial resistance problem urgently need antibiotic substitutions. Herein, we report a promising substitution of aquaculture antibiotics using a synergistic combination of biodegradable peptide polymers and curcumin, a natural compound from plant. The synergistic combination shows strong antibacterial activity against V. fluvialis and some other common bacteria in aquaculture. The membrane-damaging antibacterial mechanism echoes our finding that the synergistic combination will not induce bacteria to develop resistance after continuous use. The synergistic combination also displays effective cure on V. fluvialis-infected zebrafish. The biodegradability of the peptide polymer enables the combination to lose antibacterial activity and will not cause selective pressure on bacterial in the environment. Our study indicates potential application of synergistic composition, biodegradable peptide polymer and curcumin, as promising antibiotic substitution in aquaculture, which represents a promising strategy to address the global challenge of antimicrobial resistance.