文献类型：期刊文献

中文题名：Inverse-electron-demand Diels–Alder approach to densely substituted bicyclo[3.2.2]nonanes:Discovery of an autophagy regulator

作者：Jiulong Li[1,2];Pengxin Ren[1,2];Lin Wang[3];Yuting Zhang[3];Peng Yang[1];Weiwei He[3];Ang Li[2]

机构：[1]College of Chemistry&Henan Institute of Advanced Technology,Zhengzhou University,Zhengzhou,450001,China;[2]State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,200032,China;[3]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China

年份：2026

卷号：37

期号：5

起止页码：250

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报(英文版)

基金：supported by the National Natural Science Foundation of China(Nos.22477026,21931014,22101268,and U24A20807);Chinese Academy of Sciences(Nos.YSBR-095,XDB1060000,XBZG-ZDSYS-202303);Natural Science Foundation of Henan(No.242300420180);Science and Technology Commission of Shanghai Municipality(No.JCYJ-SHFY-2022–005);the New Cornerstone Science Foundation for the Xplorer Prize。

语种：英文

中文关键词：Bicyclo[3.2.2]nonane;Benzo[2,3]tropone;Inverse-electron-demand Diels-Alder reaction;Autophagy regulation

摘要：Natural products bearing a bicyclo[3.2.2]nonane motif pose a considerable challenge to chemical synthesis.We developed a europium-promoted inverse-electron-demand Diels–Alder reaction of benzo[2,3]tropone derivatives with electron-rich olefins,which offers an expeditious approach to densely substituted bicyclo[3.2.2]nonanes.This method enabled the concise synthesis of a tetracyclic amine,subsequently identified as a downstream suppressor of autophagy.