文献类型：期刊文献

英文题名：Cu(I)-Catalyzed Asymmetric Mannich Reaction of Glycine Schiff Bases to Ketimines

作者：Fan, Ying[1,2];Lu, Jian[1,2];Sha, Feng[1,2];Li, Qiong[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：84

期号：18

起止页码：11639

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20194107508965);WOS:【SCI-EXPANDED(收录号:WOS:000487576900025)，CCR-EXPANDED(收录号:WOS:000487576900025)】；

基金：The authors are grateful for the financial support by Shanghai Pujiang Program (18PJD010) and the Fundamental Research Funds for the Central Universities (222201814019).

语种：英文

外文关键词：Catalysis - Copper compounds

摘要：A copper-catalyzed asymmetric Mannich reaction between glycine Schiff bases and ketimines has been developed. This method afforded 2-oxindole-based chiral syn-alpha,beta-diamino acid derivatives in high yields (89-99%) with good to excellent diastereoselectivities (<= 98:2 dr) and excellent enantioselectivities (95-99% ee).