文献类型：专利

英文题名：Fermenting erythromycin, involves using composite organic nitrogen source containing soybean cake powder, cotton seed cake powder, peanut cake powder, corn steep liquor dry powder, corn protein powder, threonine, serine, and proline

作者：CHEN Y;CHU J;FENG H;GAO Y;LI W;XU X;ZHANG S;ZHUANG Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]YICHANG DONGYANGGUANG PHARM CO LTD

申请号：CN103233052-A

申请日：2013-04-11

公开日：2013-08-07

语种：英文

收录：DERWENT

摘要：NOVELTY - Method for fermenting erythromycin, involves using composite organic nitrogen source comprising 38-42 pts. wt. soybean cake powder, 9-11 pts. wt. cottonseed cake powder, 9-11 pts. wt. peanut cake powder, 18-22 pts. wt. corn steep liquor dry powder, 18-22 pts. wt. corn protein powder, and amino acid content comprising 1.74-5.15 wt.% aspartic acid, 1.72-2.19 wt.% threonine, 1.56-2.25 wt.% serine 5.25-8.01 wt.% glutamic acid, 0.63-1.88 wt.% glycine, 1.88-2.12 wt.% alanine, 0.60-1.31 wt.% methionine, 2.27-3.81 wt.% valine, and 2.14-2.38 wt.% isoleucine. USE - The method is useful for fermenting erythromycin (claimed). ADVANTAGE - The method ensures balance of total nitrogen, adequately cooperates variety of amino acids including methionine, valine, leucine and isoleucine, improves fermentation ingredients, and is cost-effective. DETAILED DESCRIPTION - Method for fermenting erythromycin, involves using composite organic nitrogen source comprising 38-42 pts. wt. soybean cake powder, 9-11 pts. wt. cottonseed cake powder, 9-11 pts. wt. peanut cake powder, 18-22 pts. wt. corn steep liquor dry powder, 18-22 pts. wt. corn protein powder, and amino acid content comprising 1.74-5.15 wt.% aspartic acid, 1.72-2.19 wt.% threonine, 1.56-2.25 wt.% serine 5.25-8.01 wt.% glutamic acid, 0.63-1.88 wt.% glycine, 1.88-2.12 wt.% alanine, 0.60-1.31 wt.% methionine, 2.27-3.81 wt.% valine, 2.14-2.38 wt.% isoleucine, 3.50-5.44 wt.% leucine, 1.33-5.36 wt.% tyrosine, 2.36-5.62 wt.% phenylalanine, 1.25-2.78 wt.% lysine, 1.88-3.18 wt.% arginine, 1.20-2.13 wt.% histidine, and 2.32-6.62 wt.% proline. An INDEPENDENT CLAIM is included for fermentation medium, which comprises 3.5-4 wt.% starch, 4-4.5 wt.% organic nitrogen compound, 0.1-0.3 wt.% ammonium sulfate, 0.2-0.6 wt.% soybean oil, 0.1-0.5 wt.% calcium carbonate, 0.01-0.02 wt.% defoaming agent, and water (remainder).