文献类型：期刊文献

中文题名：基于二氧化硫/纳米酶双锁递送系统的气体治疗/化 学动力学协同抗癌疗法

英文题名：Dual-locked SO2/nanozyme delivery nanoplatform for programmed synergistic gas/chemodynamic anticancer therapy

作者：Zhong, Tianyu[1];Zhu, Tao[3];Li, Ya[1];Wang, Shuqi[1];Jiang, Quan[3];Zhang, Yong[3];Li, Yongsheng[1,2];Cao, Yuanyuan[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & En, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China;[3]Fudan Univ, Dept Gen Surg, Zhongshan Hosp, Shanghai 200032, Peoples R China

年份：2025

卷号：68

期号：8

起止页码：2899

外文期刊名：SCIENCE CHINA-MATERIALS

收录：;EI(收录号：20252718721007);WOS:【SCI-EXPANDED(收录号:WOS:001522442200001)】；

基金：This work was supported by the National Key Research and Development Program of China (2022YFC2403200), the National Natural Science Foundation of China (22472058), the Key Field Research Program (2023AB054), the Basic Research Program of Shanghai (21JC1406003), the Shanghai Pilot Program for Basic Research (22TQ1400100-13), and the Fundamental Research Funds for the Central Universities.

语种：中文

外文关键词：gas therapy; sulfur dioxide; nanozymes; dual responsive drug delivery system; poly(ethylene glycol)-b-poly(L-lysine)

摘要：SO2 gas-therapy provides sustained assistance for augmenting the efficacy of ROS-based modalities due to its powerful tumor microenvironment-reversing capabilities. However, the inefficient delivery and insufficient generation of SO2 have greatly limited the efficacy of SO2 therapy. Herein, we designed a programmed-responsive SO2/nanozyme synergistic therapeutic nanomedicine based on the polypeptide-type copolymer of poly(ethylene glycol)-b-poly(L-lysine) (PEG-b-PLL). By taking advantage of the abundant amine groups on the PLL blocks, a dual-locked SO2 releasing system was fabricated by grafting SO2 prodrug onto the PLL blocks through GSH-responsive covalent bonds and crosslinking the remaining amine groups with disulfide-connectors to form an outer stimulation-responsive shell. Such a dual encapsulation effectively prevented the premature release of SO2 in normal cells and guaranteed its timely and sustained release, making the SO2 therapeutic processes finely coordinate with the catalytic processes of nanozymes loaded in the micellar core. The well-matching of SO2 and nanozyme resulted in the efficaciously remodeling of the tumor redox microenvironment, thus significantly enhancing the overall efficacy of chemodynamic therapy (CDT). This optimized multimodal cooperation strategy provides delicate control for improving the synergistic therapeutic efficiencies, which is anticipated to advance the ROS-based cancer treatments. (sic)(sic)(sic)(sic)(SO2)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(ROS)(sic)(sic)(sic)(sic)(sic). (sic)(sic), (sic)(sic)(sic)SO2(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)SO2(sic)(sic)(sic)(sic)(sic). (sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)-(sic)(sic)(sic)(sic)-b-(sic)(sic)(sic)(sic)(PEG-b-PLL)-(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)SO2/(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic) (sic), SO2(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(GSH)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)PLL(sic)(sic)(sic)(sic) (sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic); (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)GSH(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)SO2(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)SO2(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)SO2(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic)ROS(sic)(sic)(sic)(sic)(sic)(sic)(sic). (sic)(sic)(sic)/(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)ROS(sic)(sic)(sic)(sic)(sic)(sic)(sic)(CDT) (sic)(sic). (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)ROS(sic)(sic)(sic)(sic)(sic) (sic)(sic).