文献类型：期刊文献

英文题名：Addressing MRSA infection and antibacterial resistance with peptoid polymers

作者：Xie, Jiayang[1];Zhou, Min[1];Qian, Yuxin[2];Cong, Zihao[2];Chen, Sheng[2];Zhang, Wenjing[2];Jiang, Weinan[2];Dai, Chengzhi[2];Shao, Ning[2];Ji, Zhemin[2];Zou, Jingcheng[2];Xiao, Ximian[2];Liu, Longqiang[2];Chen, Minzhang[2];Li, Jin[3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & E, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, Shanghai Key Lab Orbital Dis & Ocular Oncol,Sch M, Shanghai 200011, Peoples R China

年份：2021

卷号：12

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000705238300022)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (Nos. 21574038, 21774031, 21861162010), Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism grant 2021 Sci & Tech 03-28 (Shanghai Municipal Education Commission), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Research Program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (JKD 01211520). The authors also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

摘要：Antibiotic resistance is a major issue in medicine and new antimicrobials for treating resistant infection are needed. Here, the authors report on antibacterial peptoid polymers, prepared via NNCA ring-opening polymerization, demonstrating antibacterial function against MRSA in vitro and in in vivo infection models. Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for antibacterial agents that are not prone to antimicrobial resistance. We prepare protease-resistant peptoid polymers with variable C-terminal functional groups using a ring-opening polymerization of N-substituted N-carboxyanhydrides (NNCA), which can provide peptoid polymers easily from the one-pot synthesis. We study the optimal polymer that displays effective activity against MRSA planktonic and persister cells, effective eradication of highly antibiotic-resistant MRSA biofilms, and potent anti-infectious performance in vivo using the wound infection model, the mouse keratitis model, and the mouse peritonitis model. Peptoid polymers show insusceptibility to antimicrobial resistance, which is a prominent merit of these antimicrobial agents. The low cost, convenient synthesis and structure diversity of peptoid polymers, the superior antimicrobial performance and therapeutic potential in treating MRSA infection altogether imply great potential of peptoid polymers as promising antibacterial agents in treating MRSA infection and alleviating antibiotic resistance.