文献类型：期刊文献

英文题名：Electrochemically Modulated Surface-Enhanced Raman Spectra of Aminoglutethimide (AGI) on a Ag-Sputtered Electrode

作者：Zhu, Zicheng[1];Espulgar, Wilfred Villariza[1];Yoshikawa, Hiroyuki[1];Saito, Masato[1,2];Fan, Bin[3];Dou, Xiaoming[1,4];Tamiya, Eiichi[1]

机构：[1]Osaka Univ, Grad Sch, Dept Appl Phys, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan;[2]Adv Photon & Biosensing Open Innovat Lab, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan;[3]Optorun, 10-1 Takeno, Kawagoe, Saitama 3500801, Japan;[4]ECUST, Grad Sch Sci, IPBM, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：91

期号：11

起止页码：1579

外文期刊名：BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

收录：;EI(收录号：20184706110525);WOS:【SCI-EXPANDED(收录号:WOS:000449706600004)】；

语种：英文

外文关键词：SERS-active screen-printed electrode; Electrochemical SERS; Aminoglutethimide detection

摘要：We have investigated the quantitative detection of aminoglutethimide (AGI) based on its adsorption on a SERS-active screen-printed electrode employing Electrochemical Surface-Enhanced Raman Spectroscopy (EC-SERS) technology. EC-SERS spectra of AGI molecules exhibited different adsorption mode onto the substrate with different potentials applied. When the applied potential reaches -400 mV, the intensities of the EC-SERS peaks provided by both aniline moiety and glutarimide moiety were significantly enhanced, which suggests the bidentate interaction of AGI molecule with the substrate. The peak of 1147 cm(-1) showed the strongest intensity among the wavenumbers, with peak intensity over 30 times stronger than that of the standard SERS signal. A linear dependence occurred in the range of 1 x 10(-5) M to 2 x 10(-7) M. The limit of detection (LOD) is 40 ng/mL and the R squared of the linear curve was 0.98. This work was completed on a coin-sized chip using low sample volume (30 mu L) only. Trace detection of this drug using this technique would be useful for the deterrence and prevention of dopant usage and other point-of-care diagnostics (POCD).