文献类型：期刊文献

英文题名：Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature

作者：Wu, Guibing[1];Wang, Jingwen[1];Liu, Chengyu[1];Sun, Maolin[1];Zhang, Lei[1];Ma, Yueyue[1];Cheng, Ruihua[2];Ye, Jinxing[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Key Lab New Drug Design, Minist Educ,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：6

期号：13

起止页码：2245

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20192707124665);WOS:【SCI-EXPANDED(收录号:WOS:000472787400010)，CCR-EXPANDED(收录号:WOS:000472787400010)】；

语种：英文

外文关键词：Transition metals - Light - Amino acids

摘要：Transition-metal-free visible-light photoredox catalyzed decarboxylative radical addition has been developed for the construction of alpha,beta-diamino esters from amino acids with glyoxylic oxime ethers under mild conditions. Cyclic and chain amino acids, dipeptides, and simple aliphatic acids are amenable to this addition as the alkyl radical source. A variety of alpha,beta-diamino esters with broad functional groups were synthesized in satisfactory yields at room temperature. The employment of acridinium as the photocatalyst and its potential scalability also demonstrate the synthetic value in practice.