文献类型：期刊文献

英文题名：Determination of trace fluoroquinolones in honey and milk based on cyclodextrin modified magnetic metal-organic frameworks solid phase extraction coupled with ultra-high performance liquid chromatography

作者：Sun, Yangkun[1];Kuang, Jingjing[1];Cheng, Yongzhe[1];Lin, Chuhui[1];Zhang, Hongyang[1];Zhang, Min[2];Ning, Fanghong[3];Hu, Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China

年份：2024

卷号：1713

外文期刊名：JOURNAL OF CHROMATOGRAPHY A

收录：;EI(收录号：20234815107161);WOS:【SCI-EXPANDED(收录号:WOS:001122990500001)】；

基金：Acknowledgments This research was funded by the National Natural Science Founda-tion of China (Grant number 81973285) .

语种：英文

外文关键词：Fluoroquinolone; Magnetic solid phase extraction; Ultra-high performance liquid chromatography

摘要：Long-term intake of animal-derived foods with excessive fluoroquinolones (FQs) will cause damage to human health, so it is critical to establish a feasible approach for sensitive and rapid monitoring of FQs residues. In this study, a new cyclodextrin modified magnetic metal-organic frameworks (Fe3O4@UiO-66-CD) was successfully synthesized by amidation reaction and applied to magnetic solid phase extraction (MSPE) for FQs analysis. The adsorption behavior of Fe3O4@UiO-66-CD was consistent with the pseudo-second-order kinetics and Freundlich isothermal adsorption model, which indicated that the designed material had various interactions on FQs, such as host-guest interaction and 7C-7C interaction. The parameters of MSPE were optimized and the determination method of norfloxacin, enrofloxacin, lomefloxacin and gatifloxacin was established by using MSPE combined with ultra-high performance liquid chromatography (UHPLC) and fluorescence detector (FLD). The method validation results displayed that the detection limits were 0.02-0.09 ng/mL, and the RSDs of intra-day and inter -day precision were less than 4.1 and 6.4 %, respectively. In the target FQs analysis of real honey and milk samples, the recoveries at different fortified concentrations were in the ranges of 88.4 % to 108.6 % with RSD <= 5.7 %. The results showed that the proposed method was sensitive, accurate and reliable for the determination of trace FQs in animal-derived foods.